“For the great day of His wrath has come, and who is able to stand?”
Revelation chapter 6 records the opening of the first six of seven prophetic seals. These show events leading up to the end-time return of Jesus Christ.
The first four seals are also known as the four horsemen of the Apocalypse, showing how false religion, war, famine and disease epidemics will grow worse and worse and lead into the time Jesus Christ called the Great Tribulation (Matthew 24:21). This is the time of the fifth seal mentioned in Revelation.
The sixth seal then reveals awesome signs in the heavens that will frighten even hardened leaders and soldiers (Revelation 6:15-16). They will try to hide from “the face of Him who sits on the throne and from the wrath of the Lamb!” (verse 16).
The great day of His wrath is another name for what is generally called the Day of the Lord throughout the Bible. The Day of the Lord begins with the opening of the seventh seal and culminates with the return of Jesus Christ to save humanity from self-destruction.
For more about the Day of the Lord, see “What Is the Day of the Lord?”